Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk

Abstract Background Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 ( NINJ2 ) a new adhesion factor. As vascular susceptibility gene, it highly expressed in other cancers and promotes growth cells. We conducted an association analysis between gene polymorphism endometrial risk. Methods Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 rs11610368 were genotyped 351 patients 344 healthy controls. The clinical index difference cases controls tested by one-way variance. allele genotype frequency been compared Chi square test. odds ratios (OR) with 95% confidence interval (95% CI) examined logistic regression analysis. Results SNP rs118050317 mutant C homozygote CC significant increased risk (OR 1.46, CI 1.04–2.06, p = 0.028; OR 8.43, 1.05–67.89, 0.045). In analysis, there higher quantities CEA, CA125 AFP serum than Conclusion loci was associated cancer. patients.